| Unlockable | How to Unlock |
| Absurd Amphibian (10 points) | Become a Frog-Clyde. |
| Ancestorial Antics (14 points) | Become an Ape-Clyde. |
| Battle Addict (12 points) | Play Versus mode. |
| Becoming Baaaad (8 points) | Become a Sheep-Clyde. |
| D.N.Ain't (16 points) | Become a Mutant-Clyde. |
| Dupliclone Dash (18 points) | Complete levels 1 to 24 and 10 Challenge levels under the goal time. |
| Foolish Freedom (20 points) | Exit 75 clones through the ventilation shafts. |
| Kenn Collection (15 points) | Collect 50 cloned Killer Kenn Action Figures. |
| Killer Kudos (25 points) | Collect 100 cloned Killer Kenn Action Figures. |
| King Clyde (20 points) | Complete all of Super-Challenge levels. |
| Master of all Clyde-Dumb (30 points) | Complete the game. |
| Poultry Party (12 points) | Become a Chicken-Clyde. |
